Chronic Oral Toxicity and Carcinogenicity of Ponceau 3R

Chronic Toxicity and Carcinogenicity of Antibacterial Zeolite "Zeomic"to Mice and Rats by Oral Administration

The antimicrobial activity of silver ions has been well known for a long time. Products in which zeolite ions are replaced with silver ions taking advantage of the ease with which zeolite ions can be exchanged in this way are used in simple water purifying equipment, for example. In recent years, moreover, they have also been adapted for use as plastic additives for use in the manufacture of a ...

On the Design and Conduct of Chronic Toxicity and Carcinogenicity

Carcinogenicity and toxicity of methoxychlor.

Methoxychlor is carcinogenic for the liver of C3H and BALB/c mice and Osborne-Mendel rats, and possibly for the liver of dogs. Methoxychlor is also carcinogenic for the testis of BALB/c male mice, bone of B6C3F1 female mice, and the ovary of Osborne-Mendel female rats. The incidences of carcinomas of the liver were increased in C3H male mice and BALB/c male and female mice fed methoxychlor. The...

3R Principle and Alternative Toxicity Testing Methods

Toxicity tests are essential for evaluating the safety or hazards of several substances. Many of the current toxicity testing methods include the use of animals, especially rodents. However, in the last three decades, there has been an inclination towards using less animals and performing alternative methods that reduce, refine and replace animal use (3R principle). The viewpoint of “reduction”...

Toxicity and Carcinogenicity Mechanisms of Fibrous Antigorite

We studied the effects of fibrous antigorite on mesothelial MeT-5A and monocyte-macrophage J774 cell lines to further understand cellular mechanisms induced by asbestos fibers leading to lung damage and cancer. Antigorite is a mineral with asbestiform properties, which tends to associate with chrysotile or tremolite, and frequently occurs as the predominant mineral in the veins of several serpe...